ADRENALINUM
An Internal Secretion of Suprarenal Glands
(ADRENALIN)
Adrenaline or Epinephrine, the lively precept of the medulla of the suprarenal gland, (cortical secretion no longer as but isolated), is employed as a chemical messenger in the law of the things to do of the body; in fact, its presence is necessary to the recreation of the sympathetic nerve. Adrenaline action on any phase is the identical as stimulation of the sympathetic nerve endings thereto. Local utility (1: 1,000 solution) to mucous membranes instantly induces transient ischemia, considered in a blanching, persisting various hours from conjunctival instillation. Its motion is very prompt, efficient, evanescent, owing to fast oxidation and consequently virtually harmless, except too often repeated, when atheroma and coronary heart lesions–myocardial–in animals have been reported. Arteries, heart, supra-renal our bodies and vaso-motor gadget are prominently affected. The important motion of Adrenaline is stimulation of the sympathetic endings, especially the splanchnic area, inflicting constriction of the peripheral arterioles, with ensuing upward push in blood pressure. This is in particular located in stomach, intestines; much less in uterus, skin; nil in talent and lungs. Furthermore, is noticed, slowing of pulse, (medullary vagus stimulation), and strengthening of coronary heart beat (increased myocardial contractility), akin to Digitalis; multiplied glandular activity, glycosuria; melancholy of respiratory center; contraction of muscular tissue of eye, uterus, vagina; leisure of muscular tissue of stomach, intestines, bladder.
Uses.–Its chief therapeutic use relies upon on its vaso-constriction action; consequently a most effective and immediate astringent and haemostatic; and precious in checking capillary haemorrhages, from all parts, the place neighborhood or direct utility is feasible: nose, ear, mouth, throat, larynx, stomach, rectum, uterus, bladder. Haemorrhagic situation now not due to faulty coagulation of the blood. Complete bloodlessness, ischemia, may also be brought about with impunity. Locally, options (1: 10,000-1: 1,000) sprayed or utilized on cotton have been very environment friendly in cold operations about the eye, nose, throat, and larynx.
Congestions of the ethmoid and sphenoid sinuses, additionally hay fever, have been markedly alleviated through heat spray of Adrenaline chloride, 1: 5,000. Here compare, Hepar 1x, which will begin up secretions and so facilitate drainage. Werlhoff’s disease, hypodermically, 1: 1,000. Externally, it has been used in neuritis, neuralgia, reflex pains, gout, rheumatism, as an ointment, 1-2 m of (1: 1,000) solution, alongside the nerve trunk at factor of pores and skin nearest its starting place which should be reached (H. G. Carlton).
Therapeutically, Adrenaline has been cautioned in acute congestion of lungs, Asthma, Grave’s and Addison’s diseases, arterio-sclerosis, continual aortitis, angina pectoris, haemophilia chlorosis, hay fever, serum rashes, acute urticaria, etc. Dr. P. Jousset reviews success in treating, homeopathically, instances of angina and of aortitis, sub-acute and chronic, when Adrenaline has been prescribed per os and in infinitesimal dose. The symptom guiding to this is, Sensation of thoracic constriction with anguish. This, with vertigo, nausea and vomiting have been produced with the aid of the drug. Abdominal pain. Shock or coronary heart failure at some point of anaesthesia, as it reasons very immediate upward push of blood strain through its motion on nerve endings in the vessel wall.
Dose.–Hypodermically, 1-5 m (1: 1,000 solution, as chloride) diluted in water. Internally, 5-30m of 1: 1,000 solution.
Caution.–On account of its affinity for oxygen, the drug without problems decomposes in watery and dilute acid solutions. The answer ought to be included from air and light. It ought to now not be too often repeated, owing to cardiac and arterial lesions. For homeopathic use 2x to 6x attenuation.
